It has long been disputed whether Kant's transcendental idealism requires two worlds ? one of appearances and one of things in themselves ? or only one. The one-world view must be wrong if it claims that individual spatio-temporal things can be identified with particular things in themselves, and if it fails to take seriously the doctrine of double affection; versions that insist on one world, without making claims about the identity of individual things, cannot say in what way the world (...) as we know it and the world of things in themselves can be ?the same?. The two-world view must be wrong if it denies Kant's empirical realism, or offers a phenomenalist interpretation of it. On moral grounds Kant ?identifies? each human person with a particular thing in itself, but the relationship here cannot be strict identity; instead its closeness may warrant regarding the two distinct entities as part of a composite whole. Perhaps up to the first edition of the Critique, Kant thought that empirical knowledge required a particular kind of close correspondence between appearances and things in themselves, one that would make it appropriate to speak of composite wholes here also. By the time of the second edition, he saw that there could be no good grounds for thinking that. In this respect something a bit like the one-world theory might make more sense for the first edition than for the second; but in both cases there is room to speak of two worlds as well. Talk of the number of worlds is metaphorical, and both metaphors have their dangers. (shrink)

Originally published: Ithaca, N.Y.: Cornell University Press, 1989. With new pref.

There are often said to be five main 'theories of truth': correspondence, coherence, pragmatic, redundancy, and semantic theories. The coherence theory of truth equates the truth of a judgment with its coherence with other beliefs. Different versions of the theory give different accounts of coherence, but in all its forms the point is to exhibit truth as an internal relation between beliefs. The pragmatic theory of truth is akin to a coherence theory of this Kantian kind. No coherence theorist need (...) deny the uncontentious claim that for a judgment to be true is for it to stand in a certain relationship, which can be called correspondence, with some state of affairs in the world. The conflict with the redundancy theory may be more apparent than real. For the redundancy theory is not a theory of what truth consists in, but a theory about the meaning of the words 'is true'. (shrink)

The four sections of the Metaphysische Anfangsgründe der Naturwissenschaft 1 are each introduced by a new definition of matter. For the Phoronomy it is defined as the movable in space (Ak. IV, 480); the other defini­tions presuppose this one. What is the status of the propositions ascribing existence to matter in these senses? Are the metaphysical principles of natural science as pure as the principles of pure understanding, or are they only required for experience which happens, in fact, to contain (...) matter as defined at the beginnings of the sections? (shrink)

Beta‐catenin is a multifunctional protein with critical roles in cell‐cell adhesion, Wnt‐signaling and the centrosome cycle. Whereas the roles of β‐catenin in cell‐cell adhesion and Wnt‐signaling have been studied extensively, the mechanism(s) involving β‐catenin in centrosome functions are poorly understood. β‐Catenin localizes to centrosomes and promotes mitotic progression. NIMA‐related protein kinase 2 (Nek2), which stimulates centrosome separation, binds to and phosphorylates β‐catenin. β‐Catenin interacting proteins involved in Wnt signaling such as adenomatous polyposis coli, Axin, and GSK3β, are also localized at (...) centrosomes and play roles in promoting mitotic progression. Additionally, proteins associated with cell‐cell adhesion sites, such as dynein, regulate mitotic spindle positioning. These roles of proteins at the cell cortex and Wnt signaling that involve β‐catenin indicate a cross‐talk between different sub‐cellular sites in the cell at mitosis, and that different pools of β‐catenin may co‐ordinate centrosome functions and cell cycle progression. (shrink)